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本文报告1957年以来法国巴黎居里研究所用(?)Co、高能射线治疗并随访至少五年的1000例头颈部恶性肿瘤中,在受照射部位发生第二个肿瘤的4个病例;复习了有关MeV 致癌作用的文献并予以分析。例1,54岁男性,1965年9月因左后舌腭沟鳞癌,用30MeV 电子线照射患部共6255rad,左下颈部选择性地给予钴疗法。65年12月并予环磷酰胺8.3克化疗,肿瘤消退。67年12月因骨坏死行左下颌骨半切除术,但检查未见有瘤细胞。69年12月发现在原发肿瘤部位的瘢痕区有一新的肿瘤生长,活检证实
This article reports on the 4 cases of the second tumor occurring at the site of irradiation in 1,000 head and neck malignancies treated with (?) Co and high-energy radiation and followed for at least five years since 1957 at the Curie Institute in Paris, France; The literature on carcinogenesis of MeV was analyzed and analyzed. Example 1, 54-year-old male, in September 1965 due to left posterior lingual squamous cell carcinoma of the tongue, a total of 6255 rad was irradiated to the affected area with a 30 MeV electron beam, and the left lower neck was selectively given cobalt therapy. In December of 1994, 8.3 g of cyclophosphamide was given to chemotherapy, and the tumor subsided. In December of 67th, a partial resection of the left mandible was performed due to osteonecrosis, but no tumor cells were observed. In December of 69, a new tumor was found in the scar area of the primary tumor site, confirmed by biopsy.