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目的探讨慢性肾功能衰竭(CRF)患者顽固性高血压(RH)应用血液透析滤过(HDF)治疗的临床疗效。方法 60例慢性肾功能衰竭顽固性高血压患者,随机分为血液透析组和血液透析滤过组,每组30例。血液透析组进行血液透析治疗,血液透析滤过组进行血液透析滤过治疗。比较治疗8周后两组患者治疗效果。结果经过8周治疗,血液透析滤过组患者治疗总有效率(93.33%)明显高于血液透析组(73.33%),差异具有统计学意义(P<0.05)。结论血液透析滤过治疗尿毒症顽固性高血压效果确切,能有效地清除血浆肾素(RA)、血管紧张素Ⅱ(AngⅡ)、甲状旁腺素等中分子毒素,治疗难治性高血压效果优于血液透析,值得临床上推广。
Objective To investigate the clinical effect of hemodialysis filtration (HDF) treatment on refractory hypertension (RH) in patients with chronic renal failure (CRF). Methods Sixty patients with refractory chronic renal failure were randomly divided into hemodialysis group and hemodiafiltration group, 30 cases in each group. Hemodialysis group hemodialysis treatment, hemodiafiltration group hemodiafiltration treatment. The therapeutic effects of two groups were compared after 8 weeks of treatment. Results After 8 weeks of treatment, the total effective rate (93.33%) in hemodiafiltration group was significantly higher than that in hemodialysis group (73.33%), the difference was statistically significant (P <0.05). Conclusion Hemodiafiltration is effective in treating refractory hypertension of uremia and can effectively remove the molecular toxins such as plasma renin (RA), angiotensin Ⅱ (Ang Ⅱ) and parathyroid hormone and treat refractory hypertension Better than hemodialysis, it is worth clinical promotion.