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本文观察定菌生治疗细菌性阴道病（ＢａｃｔｅｒｉａｌＶａｇｉｎｏｓｉｓ，简称ＢＶ）的疗效和安全性，并与对照药物（灭滴灵）进行对比观察。经临床及化验检查确诊的无心、肝、肾疾病，血尿常规正常，不合并滴虫及霉菌性阴道炎的ＢＶ病人１００例，其中８０例随机分为定菌生试验组和灭滴灵对照组，另外２０例为定菌生开放组。治疗一疗程，停药３天复查。观察结果：定菌生和灭滴灵治疗ＢＶ，临床表现总有效率分别是１００％和９５％（Ｐ＞０．０５），化验检查总有效率分别是９５％和９２．５％（Ｐ＞０．０５），两组的临床表现和化验检查总有效率差别均无显著性，两组均未出现严重副作用。观察结果表明，定菌生可做为治疗ＢＶ的安全有效药物。
This article observes the clinical efficacy and safety of Dingbiao Sheng for the treatment of bacterial vaginosis (BV), and compared with the control drug (metronidazole). Clinical and laboratory tests confirmed no heart, liver and kidney disease, hematuria routine normal, without trichomoniasis and fungal vaginitis in 100 cases of BV patients, of which 80 cases were randomly divided into fixed bacteria test group and metronidazole control group , And the other 20 cases were open-bacteria group. Treatment of a course of treatment, withdrawal 3 days review. The results showed that the total clinical efficacies of fixed bacteria and metronidazole in treatment of BV were 100% and 95%, respectively (P> 0.05). The total effective rates of laboratory tests were 95% and 92.5% (P> 0.05). There was no significant difference between the two groups in the total effective rate of clinical manifestations and laboratory tests, and no serious side effects occurred in both groups. Observations show that Ding bacteria can be used as a safe and effective treatment of BV drugs.