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目的探讨反流性食管炎(RE)的发生与幽门螺旋杆菌(HP)的相关性。方法选择我院2009年3月-2011年2月收治的102例反流性食管炎患者为观察组;另外选择我院同期收治的82例慢性浅表性胃炎患者为对照组。比较RE观察组和浅表性胃炎对照组的HP阳性率,并对RE的程度与HP感染的关系进行分析。结果观察组HP的感染率为44.1%(45/102),对照组HP的感染率为63.4%(52/82),差异有统计学意义,P<0.05。HP阴性组的Ⅱ、Ⅲ级RE的发生率均高于HP阳性组,但无显著性差异,P>0.05。结论 HP可能对RE的发病有一定抑制作用。
Objective To investigate the relationship between reflux esophagitis (RE) and Helicobacter pylori (HP). Methods A total of 102 patients with reflux esophagitis treated in our hospital from March 2009 to February 2011 were selected as the observation group. Another 82 patients with chronic superficial gastritis were selected as the control group. The positive rate of HP was compared between RE observation group and superficial gastritis control group, and the relationship between RE level and HP infection was analyzed. Results The infection rate of HP in observation group was 44.1% (45/102), while the infection rate of HP in control group was 63.4% (52/82), the difference was statistically significant (P <0.05). The incidence of grade Ⅱ and Ⅲ RE in HP-negative group was higher than that in HP-positive group, but there was no significant difference (P> 0.05). Conclusion HP may inhibit the pathogenesis of RE.