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目的：根据文献综述近年来国内外脂类炎症介质拮抗剂和抑制剂治疗哮喘的研究进展。方法：分别评价血小板活化因子拮抗剂、白三烯抑制剂及拮抗剂、血栓素Ａ２拮抗剂及血栓素合成酶抑制剂在改善哮喘炎症机制中的作用。结果：脂类炎症介质拮抗剂及抑制剂在预防和治疗哮喘中发挥了重要作用。结论：脂类炎症介质拮抗剂及抑制剂的研究是改善哮喘治疗效果的发展方向之一。
OBJECTIVE: To summarize the recent advances in the treatment of asthma with antagonists and inhibitors of lipid inflammatory mediators at home and abroad based on the literature. Methods: The effects of platelet-activating factor antagonists, leukotriene inhibitors and antagonists, thromboxane A2 antagonists and thromboxane synthase inhibitors on the mechanism of asthma inflammation were evaluated. Results: Lipid inflammatory mediators and inhibitors play an important role in the prevention and treatment of asthma. Conclusion: The study of antagonists and inhibitors of lipid inflammatory mediators is one of the development directions to improve the therapeutic effect of asthma.