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本发明公开了一种消旋卡多曲中间体2-(苄基丙烯酰胺)乙酸苄酯的制备方法,包括下述步骤:1取2-苄基丙烯酸酰卤化物与甘氨酸盐反应制成2-(苄基丙烯酰胺)乙酸备用;2取2-(苄基丙烯酰胺)乙酸与苄醇催化酯化反应制成2-(苄基丙烯酰胺)乙酸苄酯。步骤1中的2-苄基丙烯酸酰卤化物与甘氨酸盐是在有机溶剂和水相的混合相中进行,2-苄基丙烯酸酰卤化物与甘氨酸盐反应在缚酸剂存在下进
The invention discloses a method for preparing benzyl 2- (benzyl acrylamide) benzyl acetate, which comprises the following steps: 1 taking 2-benzyl acrylic acid halide and glycine salt to make 2 - (benzyl acrylamide) acetic acid for use; 2 2- (benzyl acrylamide) acetic acid and benzyl alcohol catalytic esterification reaction 2- (benzyl acrylamide) benzyl acetate. The 2-benzyl acrylic acid halide and the glycinate in Step 1 are carried out in a mixed phase of an organic solvent and an aqueous phase. The 2-benzyl acrylic acid halide is reacted with glycinate in the presence of an acid binding agent