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心得安的不良反应可分以下三种:一、通过中枢神经系统(CNS)介导的不良反应;二、周围β—肾上腺素能受体过度阻滞而出现的症状;三、特异质反应。心得安的大部分心理和行为方面的不良反应差不多都是由CNS介导造成的,故本文重点讨论这一方面。 既往对心得安在CNS的作用并未认识,随后通过动物实验一致指出,心得安可通过血脑屏障而影响中枢β—受体。常规剂量下,有时可致中枢神经功能障碍,出现头晕、疲倦、嗜睡及失眠。根据23篇文献报道的797例患者中,上述症状的发生率为3.1～4.3%。还有不少报道,服本药后出现入睡前
Adverse reactions to propofol can be divided into the following three types: one, through the central nervous system (CNS) -related adverse reactions; two, around the β-adrenergic receptor over-arrest of the symptoms; three specific reactions . Most of the adverse psychological and behavioral side-effects are almost mediated by the CNS, so this article focuses on this aspect. Past experience on the role of CNS did not know the safety, then later agreed through animal experiments that the experience may be through the blood-brain barrier affect the central beta-receptor. Conventional doses, can sometimes cause central nervous dysfunction, dizziness, fatigue, lethargy and insomnia. Among the 797 patients reported in the 23 articles, the incidence of these symptoms ranged from 3.1 to 4.3%. There are many reports, after taking this medicine before falling asleep