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目的探讨腹腔镜手术联合药物治疗对子宫内膜异位症(EM)生育能力的影响。方法确诊为Ⅰ-Ⅱ期EM并排除其他因素不孕患者142例;常规实施盆腔EM异位病灶手术后,86例使用促性腺激素释放激素激动剂(GnRH-a)(A组),56例不采用GnRH-a治疗(B组)。所有患者术后及治疗停药后均进行24个月随访,妊娠者随访至20周。比较两者妊娠率及妊娠结局情况。结果 A组总临床妊娠率高于B组(72.1%vs.48.2%)(P<0.01),A组术后1年内临床妊娠率高于B组(57.0%vs.37.5%)(P<0.05)。结论腹腔镜术后联合GnRH-a治疗可提高Ⅰ-Ⅱ期EM不孕患者的妊娠率。
Objective To investigate the effect of laparoscopic surgery combined with drug treatment on the fertility of endometriosis (EM). Methods 142 cases of infertility were diagnosed as stage Ⅰ-Ⅱ EM and other factors were excluded. After routine operation of pelvic EM ectopic lesions, 86 cases were treated with GnRH-a (group A) and 56 cases Not treated with GnRH-a (group B). All patients were followed up for 24 months after operation and after withdrawal from treatment. Pregnancy was followed up to 20 weeks. Compare the pregnancy rate and pregnancy outcome. Results The total clinical pregnancy rate in group A was significantly higher than that in group B (72.1% vs.48.2%, P <0.01). The clinical pregnancy rate in group A was significantly higher than that in group B (57.0% vs.37.5% ). Conclusions Laparoscopic surgery combined with GnRH-a can improve the pregnancy rate of Ⅰ-Ⅱ EM infertility patients.