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恶性黑素瘤的一个常见特点是能表达可被 αβCD8+细胞毒性 T淋巴细胞 (CTL)识别的多重抗原。因此 ,作者构建和测定了黑素瘤多表位痘苗病毒疫苗 (r VV.mel.pt) ,此疫苗为含 5种黑素瘤抗原的 1 0个相互连接的人类白细胞抗原 (HLA) - A2限制性 CTL表位的单一重组构建体。 作者?
A common feature of malignant melanoma is the ability to express multiple antigens that can be recognized by αβCD8 + cytotoxic T lymphocytes (CTLs). Thus, the authors constructed and assayed the melanoma multi-epitope vaccinia virus vaccine (rVV.mel.pt), which is a set of 10 interconnected human leukocyte antigens (HLA) A2 with five melanoma antigens A single recombinant construct of a restricted CTL epitope. Author?