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静脉人血丙种球蛋白因其富含Ig,对自身免疫性疾病能起到多环节、多靶点的治疗作用,且效果显著,近30 a来在临床应用方面取得很大进展,已被推荐为治疗川崎病、血小板减少性紫癜和吉兰-巴雷综合征等疾病的一线药物,也应用于所有严重或难治的自身免疫性疾病。一般大剂量使用,总量达2 g/kg,在难治性病例中甚至有每月维持治疗的方案。但费用昂贵,有一定不良反应,需注意其投入疗效比。
Because of its rich Ig, intravenous human gamma globulin can play a multi-link and multi-target therapeutic effect on autoimmune diseases with remarkable effect. In the recent 30 years, great progress has been made in clinical application and it has been recommended First-line drugs for the treatment of Kawasaki disease, thrombocytopenic purpura and Guillain-Barre syndrome and other diseases, also apply to all serious or refractory autoimmune diseases. General high-dose use, the total amount of 2 g / kg, in the treatment of refractory cases and even monthly maintenance of the program. But expensive, have some adverse reactions, should pay attention to its input than the efficacy.