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在Friedenwald对兔眼房水形成的氧化还原泵机制修改之后,学者们在兔眼的睫状突中发现了碳酸酐酶。给予醋氮酰胺可使兔眼房水中碳酸氢盐减少。从此以后,眼科临床开始应用醋氮酰胺治疗青光眼。但口服或静注醋氮酰胺和其它碳酸酐酶抑制剂常有全身副作用。偶尔,口服醋氮酰胺发生血液恶病质、肾脏损害、多毛症和药物毒性相互作用。也有不太严重的副作用,如感觉异常、呕吐、厌食、体重下降、腹部痉挛、腹泻、困倦、乏力、不适、性欲降低、阳萎、表情抑郁,使患者不能继续应用。这些常见的副作用可归纳为全身不适症候群、胃肠症候群和肾脏改变。许多学者的实验观察后指出,经兔眼的前房,结膜下注射、局部滴用或电离子导入法给予
After the Friedenwald modification of the redox pump mechanism of aqueous humor formation in rabbit eyes, carbonic anhydrase was found in the ciliary processes of the rabbit eye. Acetamide allowed the reduction of bicarbonate in rabbit aqueous humor. From then on, ophthalmology started using glaciamide in the treatment of glaucoma. However, oral and intravenous acetamide and other carbonic anhydrase inhibitors often have systemic side effects. Occasionally, oral acetazamide produces blood cachexia, kidney damage, hirsutism and drug toxicity interactions. There are also less serious side effects such as sensory abnormalities, vomiting, anorexia, weight loss, abdominal cramps, diarrhea, drowsiness, weakness, malaise, decreased sexual desire, impotence, depressed expression, so that patients can not continue to use. These common side effects can be summarized as generalized discomfort, gastrointestinal symptoms and kidney changes. Many scholars observed after the experiment pointed out that the rabbit’s anterior chamber through the eye, subconjunctival injection, topical or iontophoresis