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目的 :探讨单克隆抗体 nm2 3和 C-erb B-2在乳腺浸润性导管癌中表达与淋巴结转移关系。方法 :采用免疫组化 SP法检测了 10 0例浸润性导管癌 (其中 42例伴同侧腋窝淋巴结转移 )中 nm2 3和 C-erb B-2的表达。结果 :nm2 3的表达与腋窝淋巴结转移呈负相关 ,而与 C-erb B-2的过量表达呈正相关。结论 :nm2 3的低表达及 C-erb B-2的过量表达可作为浸润性导管癌淋巴结是否转移的一个指标 ,从而可作为评估乳腺癌预后的标记
Objective: To investigate the relationship between the expression of monoclonal antibodies nm23 and C-erb B-2 in breast invasive ductal carcinoma and lymph node metastasis. Methods: The expressions of nm23 and C-erb B-2 in 100 invasive ductal carcinomas (42 with ipsilateral axillary lymph node metastases) were detected by immunohistochemical SP method. Results: The expression of nm23 was negatively correlated with the axillary lymph node metastasis, but positively correlated with the overexpression of C-erb B-2. Conclusion: The low expression of nm23 and the overexpression of C-erb B-2 can be used as an indicator of lymph node metastasis in invasive ductal carcinoma, which may be used as a marker to evaluate the prognosis of breast cancer