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目的食管静脉曲张动物模型的建立，对研究如何预防和治疗门脉高压食管静脉曲张出血具有重要意义。以往报道的方法比较复杂，或结果不稳定，有必要加以改进。本研究的目的在于探讨犬门脉高压症食管静脉曲张模型的建立。方法16条健康成年杂种犬为研究对象，以门脉分流、丝线分段结扎完全阻断门静脉的方法建立门脉高压食管静脉曲张模型。结果16条大存活13条。经胃镜检查证实，所有存活动物均形成食管静脉曲张，其中轻度4例，中度7例，重度2例。门静脉压力达0．287P±0.073kPa、与术前0.1308±0.0294kPa相比，有显著性差异（P＜0.01）。结论与其它方法相比，本组方法较简单易行，模型质量可靠，制备周期明显缩短。
Objective The establishment of animal model of esophageal varices is of great significance for the study on how to prevent and treat the esophageal varices bleeding caused by portal hypertension. The methods reported in the past are complicated or the results are unstable and need to be improved. The purpose of this study was to explore the establishment of a model of esophageal varices in dogs with portal hypertension. Methods Twenty-six healthy adult dogs were selected as study subjects. Portal hypertension was established by means of portal vein shunting and partial ligation of silk thread. The results of 16 large surviving 13. Gastroscopy confirmed that all surviving animals were formed esophageal varices, including mild in 4 cases, moderate in 7 cases, severe in 2 cases. The portal vein pressure reached 0.287 P ± 0.073 kPa, which was significantly different from 0.1308 ± 0.0294 kPa before operation (P <0.01). Conclusion Compared with other methods, the method of this group is simpler, the quality of the model is reliable and the preparation period is obviously shortened.