吗啡、哌替啶及芬太尼对离体兔气管的影响

• 作 者: 沈健藩 林雅芳 吴倩萍
• 机 构: 南京医科大学第一附属医院麻醉科,南京医科大学第一附属医院麻醉科,Qin-huai Hospital, Nanjing 210001 南京 210029 中国,南京 210029 中国
• 出 处: Acta Pharmacologica Sinica
• 发表日期: 1994年05期
• 关键词: 电场刺激 支气管痉挛 收缩反应 北京四环制药厂 沈阳第一制药 离体器官 麻醉性镇痛药 组胺释放 气栓 气道平滑肌

用电场刺激的方法研究吗啡(Mor),哌替啶(Pet)及芬太尼(Fen)对离体兔气管的影响,结果表明:Mor 53μmol·L~(-1)使气管收缩明显增强(P<0.01);Fen 1.9 μmol·L~(-1)使其明显减弱(P<0.05);Pet 705 μmol·L~(-1)不仅使其明显减弱(P<0.01),并可使之松弛;纳洛酮(Nal)2.2 μmol·L~(-1)对气管无影响(P>0.05),但能逆转Mor对气管的效应。提示:吗啡受体的兴奋可能是引起气管平滑肌收缩的机制之一。

The effects of morphine (Mor), pethidine (Pet) and Fen on the trachea of ​​isolated rabbit were investigated by electric field stimulation. The results showed that Mor 53μmol·L -1 markedly enhanced the tracheal contraction (P <0.01), but the effect of Fen (1.9 μmol·L -1) was weakened significantly (P <0.05). Pet 705 μmol·L -1 not only attenuated it significantly (P <0.01) (Nal) 2.2 μmol·L -1 had no effect on the trachea (P> 0.05), but it could reverse the effect of Mor on the trachea. Tip: Excitatory morphine receptors may be one of the mechanisms that cause tracheal smooth muscle contraction.