论文部分内容阅读
目的 :探讨血管紧张素转换酶 (ACE)基因及血管紧张素Ⅱ 1型受体 (AT1R)基因A116 6 /C多态性与原发性高血压 (EH)及其并发脑梗死的关系。方法 :应用聚合酶链反应及PCR加酶解方法检测 15 0例健康者 (对照组 )及 15 2例EH无并发症患者 (EH组 )和 80例EH并发脑梗死患者 (EH并发脑梗死组 )ACEI/D基因多态性的ACE及AT1RA116 6C突变。结果 :EH组及EH并发脑梗死组的ACE基因的D等位基因频率为 5 0 %及 4 8% ,明显高于对照组的 33% (P <0 .0 5 )。AT1R基因的C等位基因频率在 3组之间差异无显著性意义 (P >0 .0 5 )。结论 :ACE基因可能是EH及EH并发脑梗死的重要遗传因素 ,而AT1R基因与EH发病及EH患者是否易患脑梗死无关
Objective: To investigate the relationship between angiotensin converting enzyme (ACE) gene and angiotensin Ⅱ type 1 receptor (AT1R) gene A116 6 / C polymorphism and essential hypertension (EH) and its associated cerebral infarction. Methods: Polymerase chain reaction (PCR) and polymerase chain reaction (PCR) and enzyme digestion were used to detect 15 0 healthy controls (control group) and 15 2 EH patients without complications (EH group) and 80 patients with EH complicated with cerebral infarction ) ACEI / D polymorphism of ACE and AT1RA116 6C mutations. Results: The D allele frequencies of ACE gene in EH group and EH complicated with cerebral infarction group were 50% and 48%, respectively, which were significantly higher than those in control group (P <0.05). The allele frequency of AT1R gene was not significantly different among the three groups (P> 0.05). Conclusion: ACE gene may be an important genetic factor for EH and EH complicating cerebral infarction. However, AT1R gene is not associated with EH onset and whether EH patients are susceptible to cerebral infarction