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肝脏是人体重要的解毒器官,药物进入人体后,大多要通过肝脏灭活后排出体外。肝脏又是药物代谢的主要器官,多数药物都是在肝脏内通过氧化、还原、水解,结合反应等起到转化及解毒作用。有的对肝脏有毒性,直接损害肝细胞;有的具有间接肝毒性,通过药物的中间代谢产物损伤肝细胞;有的药物通过免疫反应,使肝脏成为细胞免疫反应或体液抗体作用的器官及抗体抗原复合物沉积的部位,从而损伤肝脏。抗结核药物,长期使用可加重肝脏负担,对肝脏产生不
Liver is the body’s important detoxification organs, drugs into the body, mostly through the liver after inactivation of in vitro. The liver is the main organ of drug metabolism, most drugs are in the liver through oxidation, reduction, hydrolysis, binding reactions play a role in transformation and detoxification. Some are toxic to the liver, directly damage the liver cells; some have indirect hepatotoxicity, through the drug intermediates metabolites damage liver cells; some drugs through the immune reaction, the liver become a cellular immune response or humoral antibody effects of organs and antibodies Antigen complex deposition sites, thus damaging the liver. Anti-TB drugs, long-term use can increase the burden on the liver, the liver does not produce