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本文观察了27例病毒性肝炎肝肽素治疗前后外周血单核细胞(PBMCs)诱生的肿瘤坏死因子(TNF)水平及血清TNF水平,发现急黄肝、慢活肝、重症肝炎患者PBMCs的TNF及血清TNF水平均明显升高,(与对照组比较p<0.001),其中以重症肝炎患者的TNF水平最高。肝肽素治疗2月后,各肝炎组的TNF均下降(前后比较p<0.05),且PBMCs TNF与血清TNF有明显相关性。实验证明肝肽素能减少TNF的产生,阻断TNF对肝细胞的损伤。
In this paper, the levels of tumor necrosis factor (TNF) induced by peripheral blood mononuclear cells (PBMCs) and serum levels of TNF in 27 patients with viral hepatitis treated with hepcidin were observed. It was found that PBMCs in patients with acute yellow and chronic liver diseases and severe hepatitis TNF and serum TNF levels were significantly elevated (compared with the control group p <0.001), of which the highest levels of TNF in patients with severe hepatitis. After treatment with hepcidin for 2 months, TNF in each hepatitis group decreased (p <0.05 before and after comparison), and TNF of PBMCs was significantly correlated with serum TNF. Experiments show that heparin can reduce the production of TNF, blocking the damage of TNF on the liver cells.