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乙醇代谢主要途径分为两个阶段,其中有乙醇氧化为乙醛的乙醇脱氢酶(ADH)和乙醛氧化为乙酸的醛脱氢酶(ALDH)。乙醛的毒性是极其严重的,它是酒精性肝损害的主要物质因索,近来也有影响到染色体的报告。日本人以及其他东方人种,欠缺一部分ALDH同功酶的个体,检出率可高达30～60％,而且,由于阐明了这种情况与乙醇症的关系,这里以ALDH同功酶异常的生理意义与乙醇依存物的关系为中心,收集新的资料整理如下:
The main pathway of ethanol metabolism is divided into two stages, which are alcohol dehydrogenase (ADH) for ethanol oxidation to acetaldehyde and aldehyde dehydrogenase (ALDH) for acetaldehyde oxidation to acetic acid. The toxicity of acetaldehyde is extremely serious. It is the major causal factor of alcoholic liver damage and has recently been reported on chromosomes. Japanese and other Asians, individuals lacking a portion of ALDH isoenzymes, the detection rate can be as high as 30 to 60%, and, as elucidated the relationship between this situation and alcoholism, here ALDH isozymes abnormal physiological Meaning and dependence on ethanol as the center, collect new information as follows: