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本文对洞庭湖区东方田鼠（MF）天然抗血吸虫感染免疫特性研究表明，其新鲜血清被动转移使小鼠EPG减少40.82％－81．53％，毛蚴孵化本降低50.67％－64．76％，肝脏虫卵数减少72．07％－74．07％，肝脏虫卵肉芽肿直径比对照组短68．46－70.39μm．对血吸虫不同阶段抗原的识别特异带显示，对SSA7条、AWA和SEA各3条及CA未见阳性带．WMF和BMF血清或／和淋巴细胞杀童虫校正死亡率为64．12％－78.83％．WMF和BMF存在天然抗血吸虫抗体以SSA＞AWA＞SEA＞CA，其抗体水平在攻击感染后（BMF_(i15)）显著增高．BMF血清C_3、C_4、IL_4水平显著高于AM，在攻击感染后分别上升了74．58％、295．49％和150.88％，显示其在抗血吸虫感染中起重要作用．
In this paper, the immunological characteristics of natural anti-Schistosoma japonicum infected by Microtus fortis in the Dongting Lake area were studied. The results showed that the EPG of the mice was reduced by 40.82% -81.53% and the hatching rate of the miracidia was reduced by 50.67% -64.76% The number of eggs decreased 72.07% -74.07%. The diameter of hepatic granuloma was 68.46-70.39μm shorter than that of the control group. The specific bands of different stages of antigen identification of schistosomes showed no positive bands for SSA7, 3 for AWA and SEA, and CA. The WMF and BMF serum or / and lymphocyte kill chimpanzees mortality was 64.12% -78.83%. Natural anti-schistosome antibodies were present in WMF and BMF with SSA> AWA> SEA> CA and their antibody levels increased significantly after challenge infection (BMF_ (i15)). The levels of C_3, C_4 and IL_4 in serum of BMF were significantly higher than that of AM, and increased by 74.58%, 295.49% and 150.88% respectively after challenge infection, indicating that they play an important role in anti-schistosome infection.