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目的:观察补肾通络方对糖尿病肾病纤维化的防治作用。方法:将符合诊断标准的糖尿病肾病患者随机分为对照组和治疗组,对照组单纯用西药治疗,治疗组在西医治疗的基础上加用补肾通络方进行治疗,分别于治疗前、后抽血及收集尿液进行转移生长因子(TGF-β1)、Ⅳ型胶原纤维(CⅣ)、Ⅲ型前胶原肽(PⅢP)、纤维连接蛋白(FN)、透明质酸酶(HA)、尿蛋白、胱抑素C(CYSC)等指标的检测。结果:治疗组患者血中TGF-β1的含量由5935.62±189.61 pg/mL下降至2815.4±735.53 pg/mL;CⅣ、PⅢP、FN、HA等指标的含量分别由126.45±21.45ng/mL、10.59±2.14 ng/mL、136.35±15.56 ng/mL、145.35±20.78 ng/mL下降至72.84±10.36 ng/mL、6.23±1.24ng/mL、115.56±13.45 ng/mL、112.46±15.47 ng/mL。24小时尿蛋白由1935.62±489.61 mg/L下降至315.4±35.53 mg/L;胱抑素C的含量由3.68±1.12 mg/L下降至1.24±0.64 mg/L,与对照组比较,具有统计学意义(P<0.01)。结论:补肾通络方能缓解糖尿病肾病患者的及纤维化,对糖尿病肾病有良好的防治作用。
Objective: To observe the preventive and therapeutic effects of Bushen Tongluo Recipe on diabetic nephropathy fibrosis. Methods: Patients with diabetic nephropathy who met the diagnostic criteria were randomly divided into control group and treatment group. The control group was treated with Western medicine alone. The treatment group was treated with Bushen Tongluo Formula on the basis of Western medicine treatment. The patients were treated before and after treatment Blood and urine were collected for the detection of TGF-β1, CⅣ, PⅢP, FN, HA, urinary protein, Cystatin C (CYSC) and other indicators of detection. Results: The levels of TGF-β1 in the blood of the patients in the treatment group decreased from 5935.62 ± 189.61 pg / mL to 2815.4 ± 735.53 pg / mL, and the contents of CⅣ, PⅢP, FN and HA were 126.45 ± 21.45ng / mL and 10.59 ± 2.14 ng / mL, 136.35 ± 15.56 ng / mL and 145.35 ± 20.78 ng / mL to 72.84 ± 10.36 ng / mL, 6.23 ± 1.24 ng / mL, 115.56 ± 13.45 ng / mL and 112.46 ± 15.47 ng / mL, respectively. 24 hours urinary protein decreased from 1935.62 ± 489.61 mg / L to 315.4 ± 35.53 mg / L; the content of cystatin C decreased from 3.68 ± 1.12 mg / L to 1.24 ± 0.64 mg / L, with statistical significance Significance (P <0.01). Conclusion: Bushen Tongluo can relieve the patients with diabetic nephropathy and fibrosis, has a good preventive and therapeutic effect on diabetic nephropathy.