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本文对SLE等156例皮肤病患者同时进行抗核抗体(ANA)、循环免疫总合物(ClC)及补体第3成分(C_3)的检测。结果表明,ANA≥80倍作为阳性检出率,可提高诊断系统性红斑狼疮(SLE)、皮肌炎(DM)、进行性系统性硬化症(PSS)的异导性,但不排除其他疾病出现弱阳性的意义。ANA阳性率与病变范围及受累器官多少有一定关系,本文支持亚急性皮肤红斑狼疮(SCLE)在狼疮病谱中是SLE和慢性盘状红斑狼疮(CDLE)的中间型。ANA、ClC、C_3三变数的动态变化与肾型SLE患者病变活动性基本一致。ClC增高常见于PSS早期并可帮助发现具有心肺并发症患者。
In this paper, 156 cases of skin diseases such as SLE were simultaneously tested for ANA, ClC and C_3. The results showed that the positive detection rate of ANA≥80 times could improve the sensitivity of diagnosing systemic lupus erythematosus (SLE), dermatomyositis (DM) and progressive systemic sclerosis (PSS), but not excluding other diseases Weak positive significance. The positive rate of ANA is related to the extent of lesion and the number of affected organs. This paper supports that SCLE is an intermediate type of SLE and chronic discotic lupus erythematosus (CDLE) in lupus disease. The dynamic changes of ANA, ClC and C_3 three variables were basically the same as those of patients with renal SLE. ClC increases common in early PSS and can help find patients with cardiovascular complications.