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绝经后女性T2DM患者88例(其中正常蛋白尿(NAU)组50例,微量白蛋白尿(MAU)组38例)和对照组30例,测定其腰椎和左侧股骨近端骨密度。结果NAU组的股骨大转子的骨密度高于正常对照组(P<0.05),腰椎、股骨总量、股骨颈和wards三角骨密度呈增高趋势(P>0.05),但MAU组的大转子、wards三角区骨密度与NAU组相比有意义的降低。腰椎和股骨近端部分骨密度与体质量指数正相关,与年龄、病程、HbA1c呈负相关。结论:绝经后女性2型糖尿病正常蛋白尿时骨密度增高,但发展至微量白蛋白尿期时股骨近端可出现快速的骨丢失。NPH组。结论:地特胰岛素克服了作用时间比较短、有峰值、变异性大,易发生低血糖等缺点。
88 cases of postmenopausal women with T2DM (including 50 cases of normal proteinuria (NAU) and 38 cases of microalbuminuria (MAU)) and 30 cases of control group were measured bone mineral density of proximal lumbar and left femur. Results The BMD of NAF group was higher than that of normal control group (P <0.05). BMD of lumbar vertebra, femoral head, femoral neck and wards triangle were increased (P> 0.05) The bone density in the wards triangles was significantly reduced compared to the NAU group. The lumbar and proximal femur BMD were positively correlated with body mass index, but negatively correlated with age, course of disease and HbA1c. CONCLUSIONS: Bone mineral density is elevated in normal type 2 diabetes mellitus in postmenopausal women, but rapid bone loss can occur proximal to the microalbuminuria development in menopausal women. NPH group. Conclusion: The insulin detemir overcome the short acting time, with peak, variability, prone to hypoglycemia and other shortcomings.