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目的 探讨抑癌基因P53的缺失与胃癌发生的关系。方法 利用PCR技术对22例胃癌术后标本进行检测,观察P53基因突变和缺失情况。结果 提示胃癌组织中存在P53基因缺失,且P53基因部分缺失和胃癌病人的性别、年龄及胃癌分化程度有关或很密切。结论 胃癌的发生与P53基因缺失密切相关。
Objective To investigate the relationship between the loss of tumor suppressor gene P53 and the occurrence of gastric cancer. Methods Twenty-two specimens of gastric cancer were detected by PCR and observed for mutation and deletion of P53 gene. The results suggest that there is a deletion of P53 gene in gastric cancer tissues, and the partial deletion of P53 gene is closely related to the gender, age, and differentiation degree of gastric cancer patients. Conclusion The occurrence of gastric cancer is closely related to the deletion of P53 gene.