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目的探讨混合性中风的实验动物模型的制作方法，从而了解其发病机理。方法利用１８０只肾血管性高血压鼠（ＲＨＲｓ）通过升高或降低血压来改变血流动力学，及加用纤维蛋白原后再升高或降低血压，注意控制药物剂量及持续时间来引发脑卒中。筛选出梗塞出血并存的动物模型。结果发现加用纤维蛋白原（２００±５０）ｍｇ后，利血平０３ｍｇ，间隔２ｈ注射３次组引发混合性中风的发生率最高，达９５％。受损部位以小脑、内囊、皮质、海马、丘脑为多，以大梗塞－小出血型中风为多，梗塞以小脑、海马为著。这些梗塞灶和出血灶都在２４ｈ内发生。结论长期高血压脑动脉硬化是混合性中风的病理基础，血压剧烈的波动和血液粘滞度的变化是引起混合性中风的重要因素。
Objective To explore the method of making experimental animal model of mixed stroke to understand its pathogenesis. Methods 180 hemiresenteric rats (RHRs) were used to change the hemodynamics by increasing or decreasing blood pressure, and then increasing or decreasing the blood pressure by adding fibrinogen. Attention was paid to controlling the dosage and duration of the drug to induce the brain Stroke. Animal models of infarction and bleeding were selected. The results showed that with fibrinogen (200 ± 50) mg, reserpine 0 3mg, 2h interval injection 2 times the incidence of mixed stroke highest incidence of 95%. Damaged parts of the cerebellum, internal capsule, cortex, hippocampus, thalamus and more to large infarcts - small hemorrhage stroke as much infarction to the cerebellum, the hippocampus. These infarcts and hemorrhagic lesions occur within 24 hours. Conclusion Long-term hypertensive cerebral arteriosclerosis is the pathological basis of mixed stroke. Severe fluctuations of blood pressure and changes of blood viscosity are the important factors that cause mixed stroke.