论文部分内容阅读
目的探讨动脉导管持续开放对早产儿的影响和危害。方法采用回顾性调查研究,选择2007—2010年我院新生儿科住院治疗的动脉导管未闭(PDA)早产儿,根据出院时或死亡前动脉导管关闭情况分为动脉导管关闭组和动脉导管持续开放组。比较两组早产儿相关并发症的发生情况、氧疗情况、预后及住院费用等多方面的差异。结果动脉导管持续开放组(59例)发生充血性心力衰竭、喂养不耐受和Ⅲ～Ⅳ级脑室内出血的比例、需要呼吸支持的比例及用氧时间均高于动脉导管关闭组(112例),差异有统计学意义[50.8%比32.1%,33.9%比17.9%,8.5%比0.9%,66.4%比32.1%,7.0天(3.0,13.0)比6.0天(0,9.8),P均<0.05];两组发生NEC、Ⅰ～Ⅱ级脑室内出血、支气管肺发育不良和早产儿视网膜病的比例差异无统计学意义(P>0.05)。导管持续开放组住院时间和住院费用均多于动脉导管关闭组[(26.3±14.9)天比(20.0±12.9)天,(21079±13166)元比(17761±10849)元,P均<0.05]。结论动脉导管持续开放可使早产儿相关并发症增加,对呼吸支持的要求增多,也增加了住院时间和费用。
Objective To investigate the effect and harm of continuous catheterization on premature infants. Methods A retrospective study was conducted to select preterm infants with patent ductus arteriosus (PDA) who were hospitalized in neonates of our hospital from 2007 to 2010. According to the closure of the ductus arteriosus before discharge or death, the patients in the arterial catheterization group and the arterial catheter were continuously open group. Compare the incidence of complications related to premature children in the two groups, oxygen therapy, prognosis and hospitalization costs and other differences. Results The proportion of patients with congestive heart failure, feeding intolerance and intracerebral hemorrhage of grade Ⅲ ~ Ⅳ, the proportion of patients requiring respiratory support and the time of using oxygen were higher than those of patients with patent ductus arteriosus (n = 112) , The difference was statistically significant (P <0.05). The difference was statistically significant (50.8% vs 32.1%, 33.9% vs 17.9%, 8.5% vs 0.9%, 66.4% vs 32.1%, 7.0 days vs 3.0, 13.0 vs 6.0 days 0.05]. There was no significant difference in the incidence of NEC, grade Ⅰ ~ Ⅱ intraventricular hemorrhage, bronchopulmonary dysplasia and retinopathy of prematurity between the two groups (P> 0.05). The duration of hospitalization and hospitalization in the continuous open group were significantly higher than those in the patent ductus arteriosus closed group [(26.3 ± 14.9 days vs 20.0 ± 12.9 days, (21079 ± 13166) yuan (17761 ± 10849) yuan, P <0.05] . Conclusion The continuous open ductus arteriosus can increase the complications associated with premature infants, increase the demand for respiratory support, and increase the length of hospital stay and costs.