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目的为了研究胃癌发生发展的机理。方法采用免疫组化方法研究了８８例胃癌及其癌旁肠上皮化生、异型增生中Ｐ５３和ｃ－ｅｒｂＢ－２基因蛋白的表达。结果８８例胃癌中Ｐ５３和ｃ－ｅｒｂＢ－２蛋白阳性率分别为５２．３％和２０．５％；Ｐ５３在高分化腺癌和低分化腺癌的阳性率（分别为６１．８％和５７．９％），明显高于粘液癌（１８．８％，Ｐ＜０．０１）；癌旁肠上皮化生和异型增生中Ｐ５３全部为阴性；ｃ－ｅｒｂＢ－２在高分化腺癌和低分化腺癌中的阳性率有显著性差异（Ｐ＜０．０５）；癌旁肠上皮化生中ｃ－ｅｒｂＢ－２全部为阴性，中度以上不典型增生阳性率４．８％。结论Ｐ５３基因突变和ｃ－ｅｒｂＢ－２基因活化是胃粘膜上皮癌变的重要原因和标志。
Objective To study the mechanism of the development of gastric cancer. Methods Immunohistochemistry was used to study the expression of P53 and c-erbB-2 gene proteins in 88 cases of gastric cancer and its adjacent para-intestinal metaplasia and dysplasia. Results The positive rate of P53 and c-erbB-2 protein was 88.8% and 20.5% in 88 cases of gastric cancer respectively; the positive rate of P53 in well-differentiated adenocarcinoma and poorly differentiated adenocarcinoma (61.8% and 57, respectively). (9%) was significantly higher than that of mucinous carcinoma (18.8%, P<0.01); P53 was negative in para-intestinal metaplasia and dysplasia; c-erbB-2 was in well-differentiated adenocarcinoma and low There was a significant difference in the positive rate of differentiated adenocarcinoma (P<0.05); all of the c-erbB-2 in paratumor metaplasia were negative, and the positive rate of moderate to moderate dysplasia was 4.8%. Conclusion P53 gene mutation and c-erbB-2 gene activation are important causes and signs of gastric epithelial carcinoma.