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目的分析探讨家庭随访对低抗凝血酶(AT)水平的持续非卧床腹膜透析(CAPD)患者心血管事件发生风险的影响。方法选取确治疗的接受CAPD治疗的慢性肾衰竭患者共185例进行研究,随机分为两组,其中家庭随访组患者90例,另外95例患者为对照组;研究比较两组患者相关信息,随访比计较2年后心血管事件发生情况;采用SPSS 17.0软件分析数据。结果本研究中家庭随访组中AT≤230 mg/L者与AT>230 mg/L者比较仅见尿量≤500 ml者的比例AT≤230 mg/L者更高(P<0.05);对照组中也仅发现AT≤230 mg/L者尿量≤500 ml的比例更高(P<0.05),符合病理特征。随访比较受试对象心血管事件发生情况:干预后AT≤230 mg/L的受试对象中心血管事件发生率为22.58%,心血管事件死亡率为3.23%,无心血管事件时间平均为(425.36±39.87)d,心血管事件死亡率为3.23%;与同组AT>230 mg/L者比较可见心血管事件发生率更高,无心血管事件时间更短(P<0.05)。而与常规对照组AT≤230mg/L者相比,心血管事件发生率均较低,无心血管事件时间均较长(P<0.05);常规对照组内AT≤230 mg/L的受试对象与AT>230 mg/L者相比较可见心血管事件发生率更高,无心血管事件时间更短(P<0.05)。结论提示低AT表达者心血管事件预后情况普遍更为严重,而家庭随访干预对于全部患者均有一定的控制减低心血管事件发生风险的作用。
Objective To investigate the effect of home-visit on the risk of cardiovascular events in patients with continuous ambulatory peritoneal dialysis (CAPD) with low antithrombin (AT) level. Methods A total of 185 patients with chronic renal failure treated with CAPD were enrolled and randomly divided into two groups, 90 patients in the family follow-up group and 95 patients in the control group. The relative information and the follow-up of the two groups were compared Calculate the occurrence of cardiovascular events more than 2 years later; use SPSS 17.0 software to analyze the data. Results In this study, AT ≤ 230 mg / L in family follow-up group was higher than that of AT> 230 mg / L in patients with urine volume ≤ 500 ml (AT≤ 230 mg / L) Also found only AT ≤ 230 mg / L urine output ≤ 500 ml higher proportion (P <0.05), in line with the pathological features. Follow-up comparison of cardiovascular events: subjects with AT≤230 mg / L had central cardiovascular events of 22.58%, cardiovascular events mortality of 3.23%, and mean time of non-cardiovascular events of 425.36 ± 39.87) d. The cardiovascular mortality rate was 3.23%. Compared with AT> 230 mg / L group, the incidence of cardiovascular events was higher and the duration of cardiovascular events was shorter (P <0.05). Compared with the conventional control group AT ≤ 230mg / L, the incidence of cardiovascular events were lower, no longer cardiovascular events were longer (P <0.05); conventional control group AT ≤ 230 mg / L of the subjects Patients with AT> 230 mg / L showed a higher incidence of cardiovascular events and shorter cardiovascular events (P <0.05). The conclusion suggests that the prognosis of cardiovascular events in patients with low AT expression is generally more serious, and family follow-up intervention for all patients have a certain degree of control to reduce the risk of cardiovascular events.