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研究前胸腺素α(PTMA)在膀胱移行细胞癌组织中的表达情况,并分析其与膀胱癌临床病理特征的关系。方法:选择96例膀胱移行细胞癌标本,10例癌旁正常膀胱组织标本。采用免疫组化检测膀胱癌和癌旁正常组织中PTMA蛋白的表达。癌标本中非肌层浸润性癌51例,肌层浸润性癌45例;单发肿瘤57例,多发肿瘤39例;G122例、G231例、G343例;非肌层浸润性癌中未复发29例,复发22例。结果:随病理分级和临床分期增加,PTMA相对表达量逐渐增高。G1、G2、G3膀胱癌PTMA蛋白表达阳性率分别为13.6%、32.3%,62.8%,均差异有统计学意义(P<0.05)。正常膀胱组织中无PTMA蛋白表达。非肌层浸润性肿瘤和肌层浸润性肿瘤中PTMA蛋白表达阳性率为37.3%和77.8%,差异有统计学意义(P=0.0002)。随访12～60个月,非肌层浸润性膀胱癌中,复发组与未复发组中PTMA蛋白高表达阳性率为68.2%和31.0%,差异有统计学意义(P<0.001))。结论:检测膀胱移行细胞癌组织中PTMA有助于膀胱癌的诊断及评估判断,PTMA蛋白高表达与膀胱尿路上皮癌的恶性程度及预后相关。
To investigate the expression of PTMA in transitional cell carcinoma of the bladder and its relationship with the clinicopathological features of bladder cancer. Methods: 96 cases of bladder transitional cell carcinoma specimens and 10 cases of adjacent normal bladder tissue samples were selected. Immunohistochemistry was used to detect the expression of PTMA protein in bladder cancer and adjacent normal tissues. There were 51 cases of non-muscular invasive carcinoma and 45 cases of myometrial invasive carcinoma in cancerous specimens, 57 cases of single tumor and 39 cases of multiple tumors, G122 cases, G231 cases and G343 cases, and non-muscle invasive carcinoma 29 Cases, recurrence in 22 cases. Results: With the increase of pathological grade and clinical stage, the relative expression of PTMA increased gradually. The positive rates of PTMA protein expression in G1, G2 and G3 were 13.6%, 32.3% and 62.8%, respectively, with statistical significance (P <0.05). No normal bladder tissue PTMA protein expression. The positive rates of PTMA protein expression in non-muscle invasive tumors and myometrial invasive tumors were 37.3% and 77.8%, respectively, with statistical significance (P = 0.0002). The positive rates of PTMA protein in recurrence group and non-recurrence group were 68.2% and 31.0% respectively in non-muscle invasive bladder cancer at follow-up of 12 to 60 months. The difference was statistically significant (P <0.001). Conclusion: Detecting PTMA in bladder transitional cell carcinoma can be helpful to the diagnosis and evaluation of bladder cancer. The high expression of PTMA protein is associated with the malignancy and prognosis of bladder urothelial carcinoma.