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OBJECTIVE To evaluate the applicability of combined therapy and the prognostic factors in patients with carcinoma of the cervical stump (CCS).METHODS The clinical records of 60 CCS patients who underwent combined treatment in our hospital during a period from January 2000 to December 2007, were collected and retrospectively analyzed. The prognostic factors were studied using univariate analysis. Analytical evaluation of the independent prognostic factors was performed using COX proportional-hazards regression model.RESULTS The 1-, 3- and 5-year survival rates of the 60 patients were 95%, 78% and 68%, respectively, with a median survival time of 32 months. Univariate survival analysis showed that these independent prognostic factors included positive pelvic lymph nodes (P = 0.001), lymphovascular tumor embolus (P = 0.001), and adjuvant chemotherapy (P = 0.011). In the 60 cases, postoperative local recurrence in the pelvic cavity occurred in 1 and distant metastasis in 3. Related complications, such as radiocystitis, recto-vaginal fistula and vesico-vaginal fistula were found in 6 of the total cases (10%). The serum levels of squamous epithelium antigen detected before and after treatment were significantly different (P = 0.000). The incidence of CCS is low; however, the disease is difficult to cure due to the high incidence of complications and to the frequency of distant metastasis. Therefore, individualized treatment is needed. Complications from subtotal hysterectomy (STH) should be treated and controlled aggressively. Careful follow-up as well as close monitoring and observation for significant symptoms in the postoperative course will enhance clinical outcome.CONCLUSION Cancer of the cervical stump has a low morbidity and severe complications, and most recurrences are distant metastases. Because it is difficult to cure, there is a need to design a treatment regimen for each individual patient based on the factors deemed as high risk. The surgical indications for subtotal uterine resection should be followed and close follow-up after surgery should be maintained.