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[目的]研究成年期体质指数(BMI)与上海市区居民膀胱癌危险性的关系。[方法]采用全人群病例对照研究,共调查1996年1月1日～1998年12月31日期间诊断的上海市区膀胱癌新发病例608例,以及性别、年龄配对的人群对照607例。采用非条件Logistic回归模型,调整可能的混杂因素,估计20岁时、成年期最高体重时及参考年份前10年内BMI与膀胱癌发生的比数比(ORs)和95%可信区间(CIs)。[结果]随着20岁时BMI的增加,男性膀胱癌发生的危险性也增加。与四分位数最低组相比,其他各组的OR值分别为1.51(95%CI:1.01～2.25)、2.24(95%CI:1.52～3.31)和1.80(95%CI:1.20～2.69),趋势检验有统计学意义(P=0.001)。未发现成年期最高体重时及参考年份前10年内BMI与男性膀胱癌的发生有统计学关联。女性成年期各个阶段BMI均与膀胱癌的发生有关。与BMI四分位数最低组相比,三个不同阶段四分位数最高组的OR值分别为3.27(95%CI:1.52～7.03)、2.23(95%CI:1.08～4.60)和3.63(95%CI:1.68～7.85),各组趋势检验均有统计学意义。[结论]男性成年初期BMI可能与膀胱癌的发生有关,女性成年期各阶段的BMI均与膀胱癌的发生有关。
[Objective] To study the relationship between adult body mass index (BMI) and the risk of bladder cancer in urban residents in Shanghai. [Methods] A population-based case-control study was conducted to investigate 608 newly diagnosed cases of bladder cancer in Shanghai city from January 1, 1996 to December 31, 1998, as well as 607 control subjects matched by gender and age. Non-conditional logistic regression models were used to adjust for possible confounders to estimate odds ratio (ORs) and 95% confidence intervals (CIs) for BMI and bladder cancer at 20 years of age, at highest adult weight, and at 10 years prior to the reference year . [Results] With the increase of BMI at the age of 20, the risk of bladder cancer in men also increased. The odds ratios for the other groups were 1.51 (95% CI: 1.01-2.25), 2.24 (95% CI 1.52-3.31) and 1.80 (95% CI 1.20-2.69), respectively, compared with the lowest quartile , Trend test was statistically significant (P = 0.001). No significant association was found between BMI and the incidence of bladder cancer in men before the highest adult weight and in the first 10 years of the reference year. BMI in all stages of female adult is related to the occurrence of bladder cancer. Compared with the lowest quartile of BMI, OR of the highest quartile of the three different quartiles were 3.27 (95% CI: 1.52-7.03), 2.23 (95% CI: 1.08-4.60) and 3.63 95% CI: 1.68 ~ 7.85), the trend test in each group was statistically significant. [Conclusion] BMI may be related to the occurrence of bladder cancer in males in early adulthood. The BMI in all stages of adulthood is related to the occurrence of bladder cancer.