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目的观察促排卵后超声下行未成熟卵泡穿刺术(IMFP)治疗多囊卵巢综合征(PCOS)的效果。方法选择多囊卵巢综合征患者共86人,分2组。观察组43例,穿刺前用少量人类尿促性腺激素(HMG)促排卵;对照组43例,穿刺前未用HMG。在超声引导下行未成熟卵泡抽吸术,尽可能将能看到的卵泡全部抽吸干净,连续2～3个周期,穿刺后检查患者的内分泌和卵巢基础窦卵泡计数,直至达到基础窦卵泡计数≤10个/卵巢,并随访6个月记录其妊娠情况。结果两组患者窦卵泡计数、LH、LH/FSH、T值均较术前降低;卵巢过度刺激综合征发生率降低而妊娠率升高,其中观察组效果优于对照组(P<0.01)。结论超声引导下IMFP可在一定时间内有效改善PCOS患者的内分泌状态,明显减少卵巢内窦卵泡计数,使其在以后的促排卵周期中OHSS发生率降低,排卵率及妊娠率提高,是治疗重度PCOS的一种有效途径。
Objective To observe the effect of immature follicular puncture (IMFP) on polycystic ovary syndrome (PCOS) after ovulation induction. Methods A total of 86 patients with polycystic ovary syndrome were selected and divided into two groups. In the observation group, 43 cases were given ovulation induction with a small amount of human urogenital gonadotropin (HMG) before puncturing. In the control group, 43 cases were given HMG without puncture. Ultrasound-guided immature follicle aspiration, as far as possible will be able to see the follicles all the suction clean, continuous 2 to 3 cycles, check the patient’s endocrine puncture and ovarian basal antral follicle count until it reaches the basal antral follicle count ≤10 / ovary, and follow-up of 6 months to record their pregnancy. Results The antral follicle count, LH, LH / FSH and T decreased in both groups. The incidence of ovarian hyperstimulation syndrome decreased while the pregnancy rate increased. The observation group was better than the control group (P <0.01). Conclusion Ultrasound-guided IMFP can effectively improve the endocrine status of patients with PCOS in a certain period of time, significantly reduce the count of ovarian follicles in antral so that in the subsequent ovulation cycle OHSS incidence decreased, ovulation and pregnancy rates, is the treatment of severe An effective way of PCOS.