论文部分内容阅读
目的探讨系统性红斑狼疮(SLE)患者血清中抗中性粒细胞胞浆抗体(ANCA)的阳性检出率及其与SLE病情的相关性。方法应用间接免疫荧光技术(IIF)和ELISA方法检测,并结合肾穿刺活检明确肾脏病理。结果67例SLE患者中,ANCA阳性16例,阳性率23.9%。其中P-ANCA阳性者15例,阳性率22.4%;C-ANCA阳性1例,阳性率1.5%。ANCA阳性组中抗dsDNA抗体阳性、低补体血症及中度以上贫血者明显高于阴性组。肾穿刺活检病例中ANCA阳性组肾脏活动性病变指数高于ANCA阴性组。结论ANCA在SLE患者中有一定的阳性检出率,且与疾病的活动状态呈正相关。
Objective To investigate the positive detection rate of serum anti-neutrophil cytoplasmic antibody (ANCA) in patients with systemic lupus erythematosus (SLE) and its correlation with SLE. Methods The indirect immunofluorescence technique (IIF) and ELISA were used to detect the renal pathology in combination with the renal biopsy. Results Of the 67 SLE patients, ANCA positive in 16 cases, the positive rate of 23.9%. P-ANCA positive in 15 cases, the positive rate of 22.4%; C-ANCA positive in 1 case, the positive rate of 1.5%. ANCA-positive group anti-dsDNA antibody-positive, hypocomplementemia and moderate to severe anemia was significantly higher than the negative group. Renal biopsy cases ANCA positive group renal active lesions index higher than ANCA negative group. Conclusion ANCA has a positive detection rate in patients with SLE and is positively correlated with the activity of the disease.