披针形杜茎山中三萜皂苷抗病毒、溶血及灭螺活性的构效关系

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披针形杜茎山(拟)Maesa lanceolata在西非民间用于预防霍乱。据报道,从其干叶甲醇提取物中分得的三萜皂苷混合物显示中等的细胞外杀HSV-1活性、明显的溶血活性,并对光滑双脐螺Biomphalaria glabrata有强烈毒性。作者用半制备HPLC法分离此混 The lanceolate-shaped stem of the genus Maesa lanceolata is used to prevent cholera in West Africa. It has been reported that the triterpene saponin mixture obtained from the methanol extract of dry leaves showed moderate extracellular HSV-1 activity, significant hemolytic activity, and strong toxicity to the smooth double umbilicus Biomphalaria glabrata. The author isolated the mixture using semi-preparative HPLC
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