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目的加深对乳腺上皮性病变的认识,提高病理冷冻切片诊断的准确率。方法收集乳腺上皮性病变术中冷冻切片745例,按照WHO(2003)乳腺肿瘤组织学分类诊断标准对照石蜡切片分析误诊及延迟诊断原因,总结诊断规律。结果745例乳腺上皮性病变的冷冻切片中,3例误诊为浸润性导管癌、髓样癌和实性神经内分泌癌,分别是由于取材、制片及认识不足所致(0.4%),均为假(-);延迟诊断34例(4.56%),其中导管原位癌、不典型导管增生和导管内乳头状瘤延迟诊断率较高。结论乳腺上皮性病变具有形态多样性和易混淆性,有必要提高对冷冻切片诊断的认识水平和经验。
Objective To deepen the understanding of mammary epithelial lesions and improve the diagnostic accuracy of pathological frozen sections. Methods 745 cases of intraepithelial neoplasia were collected. According to WHO (2003) diagnostic criteria for histological classification of breast tumors, paraffin sections were analyzed for misdiagnosis and delayed diagnosis, and the diagnostic rules were summarized. Results Of 745 frozen epithelial lesions, 3 were misdiagnosed as invasive ductal carcinomas, medullary carcinomas and solid neuroendocrine carcinomas, which were all due to lack of materials, production and knowledge (0.4%), all of which were False (-); Delayed diagnosis in 34 cases (4.56%), of which ductal carcinoma in situ, atypical ductal hyperplasia and ductal papilloma delayed diagnosis rate. Conclusion Breast epithelial lesions are morphologically diverse and confusing. It is necessary to improve the level of knowledge and experience in the diagnosis of frozen sections.