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Pie-3-HCl是新合成的呱嗪类药物,本实验观察其对正常大鼠,自发性高血压大鼠的降压作用及血液动力学的影响,并对降压机制进行了研究。 方法与结果 一、对正常麻醉大白鼠血压的影响: 大鼠10只,均分两组,分别iv Pie-3-HCl 2.5及5 mg/kg,以生理盐水作自身对照,结果表明,两两个剂量组的Pie-3-HCl均可使收缩压和舒张压显著降低,2.5 mg/kg组给药10及20 min时收缩压分别下降29.7％和27.2％,舒张压分别下降40.7％和43.9％,降压同时心率减慢。
Pie-3-HCl is a newly synthesized piperazine drug. The effect of Pie-3-HCl on the antihypertensive effect and hemodynamics in normal rats and spontaneously hypertensive rats was observed. The antihypertensive mechanism was also studied. Methods and results A, the impact of normal anesthetized rats blood pressure: 10 rats were divided into two groups, respectively, iv Pie-3-HCl 2.5 and 5 mg / kg, with saline as their control, the results showed that two and two The systolic and diastolic blood pressures of Pie-3-HCl group were significantly lower than those of the control group. Systolic blood pressure decreased by 29.7% and 27.2% at 10 and 20 min after administration of 2.5 mg / kg, while the diastolic blood pressure decreased by 40.7% and 43.9 %, Depressurization and heart rate slow down at the same time.