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急性淋巴细胞白血病(ALL)中具有成熟特征的白血病细胞的形态为:细胞体较原始淋巴细胞小,象成熟的淋巴细胞一样,细胞核染色质致密,无明显的核仁。在骨髓涂片,若这样的细胞占全部有核细胞的20％以上,诊断为伴有成熟特征的急性淋巴细胞白血病(ALLm);若这样的细胞占全部有核细胞的20％以下,诊断为典型的急性淋巴细胞白血病(ALLt)。 作者对101例ALL(按FAB分类标准)中的19例ALLm和82例ALLt的诱导治疗反应和其它预后因素如血液学表现、免疫表型、Pgp表达、P53蛋白和染色体进行了研究。ALLm患者平均年龄为29±18岁,比ALLt患者(18±16)大(P<0.015)。
The morphology of leukemia cells with mature features in acute lymphoblastic leukemia (ALL) is that the cell body is smaller than the original lymphocytes, and like the mature lymphocytes, the nuclear chromatin is compact and there is no obvious nucleoli. In bone marrow smears, if such cells account for more than 20% of all nucleated cells, diagnosed as acute lymphoblastic leukemia (ALLm) with mature characteristics; if such cells account for less than 20% of all nucleated cells, diagnosed as Typical acute lymphoblastic leukemia (ALLt). The authors studied the induction of treatment response and other prognostic factors such as hematological findings, immunophenotype, Pgp expression, P53 protein, and chromosomes in 19 cases of ALL (according to FAB classification criteria) of 19 cases of ALLm and 82 cases of ALLt. The average age of patients with ALLm was 29±18 years, which was greater than that of patients with ALLt (18±16) (P<0.015).