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作者对一组75名即将绝经的踺康妇女的骨量和骨细胞功能进行了长达9年的纵向研究。受试者年龄均在46岁以上,健康并仍有月经,且绝经过程十分自然。绝经前每隔6个月对这些妇女进行骨量、血清雌二醇和促性腺激素的系列测定。受试者饮食中的钙为651±246mg/d,磷为1005±243mg/d。应用 Norland 双光子骨密度仪和 BONES-TAR 软件测量腰椎和金身的骨量。应用单光子骨密度仪测量桡骨。用 Coat-A-Count kit 测定雌激素,用 Combostat kit 测定促性腺激素。用回归的方法分析骨量测量值,计算出每个受试者不同部位
The authors conducted a nine-year longitudinal study of bone mass and osteocyte function in a group of 75 healthy women undergoing menopause. Subjects were over 46 years of age, healthy and still have menstruation, and the process of menopause is very natural. A series of measurements of bone mass, serum estradiol, and gonadotropin levels were performed on these women six months prior to menopause. Dietary calcium in subjects was 651 ± 246 mg / day and phosphorus was 1005 ± 243 mg / day. The bone mass of the lumbar vertebrae and the golden body was measured using the Norland two-photon bone densitometer and the BONES-TAR software. Radius was measured using a single photon bone density meter. Estrogen was measured using the Coat-A-Count kit and gonadotrophin was measured using the Combostat kit. Bone measurements were analyzed by regression and different parts of each subject were calculated