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通过用异丙肾上腺素造成的大鼠心肌缺血模型,观察飞龙掌血(Toddaliaasiaticalam)水提物(飞龙一号,F01)对心肌过度兴奋所致心肌缺血的保护作用。结果显示:F01(525mg·kg1)能明显缓解心电图T波改变,其作用与维拉帕米及普萘洛尔相似,但对心率的影响与上述两药明显不同。表明F01对心脏过度兴奋所致心肌缺血有保护作用,此作用可能与其抑制Ca2+转运导致的心肌细胞内Ca2+减少有关。
By using a rat model of myocardial ischemia induced by isoproterenol, the protective effect of the Toddalia asiatical amyloid extract (Feilong I, F01) on myocardium ischemia induced by hyperexcitability of the myocardium was observed. The results showed that F01 (525 mg·kg1) can significantly ease the T wave changes of electrocardiogram, and its effects are similar to those of verapamil and propranolol, but the effect on heart rate is obviously different from the above two drugs. It was shown that F01 has a protective effect on myocardial ischemia induced by hyperexcitability of the heart, and this effect may be related to its inhibition of Ca2+ reduction caused by Ca2+ transport in the myocardial cell.