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目的探讨COX-2和Ki-67在甲状腺肿瘤组织中表达的意义,分析其与肿瘤生物学特征及患者术后生存时间的相关性。方法通过免疫组织化学方法检测有完整随访资料的68例甲状腺癌和40例正常甲状腺组织中COX-2和Ki-67的表达,对所有数据采用SPSS16.0统计学软件进行分析。结果 COX-2、Ki-67在癌组织中的表达率(60.29%、67.64%)高于正常组织中表达率(2.5%、27.5%),差异有统计学意义(P<0.05);COX-2、Ki-67的表达与肿瘤的大小、分化程度、浸润深度、TNM分期及远处转移均呈正相关(P<0.05);COX-2和Ki-67表达阳性组患者5年生存率较正常对照组均低(P<0.05)。结论 COX-2和Ki-67可作为甲状腺癌早期诊断和判断预后的指标,能指导临床上对肿瘤生物学性状评价。
Objective To investigate the significance of expression of COX-2 and Ki-67 in thyroid tumor and their relationship with tumor biological characteristics and postoperative survival time. Methods The expressions of COX-2 and Ki-67 in 68 cases of thyroid carcinoma and 40 cases of normal thyroid tissue with complete follow-up data were detected by immunohistochemistry. All the data were analyzed by SPSS16.0 statistical software. Results The expression rates of COX-2 and Ki-67 in cancer tissues were higher than those in normal tissues (2.5%, 27.5%, 60.29%, 67.64%, P <0.05) The expression of Ki-67 was positively correlated with tumor size, differentiation, depth of invasion, TNM stage and distant metastasis (P <0.05). The 5-year survival rate of patients with positive COX-2 and Ki-67 expression was significantly higher than that of normal Control group were low (P <0.05). Conclusions COX-2 and Ki-67 can be used as indicators for the early diagnosis and prognosis of thyroid cancer, which can guide the clinical evaluation of tumor biological characteristics.