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目的探讨131碘(131I)对甲亢性心脏病(甲亢心)患者的一氧化氮(NO)和内皮素(ET)水平的影响。方法用131I治疗甲亢心患者36例,分别观察治疗前后血NO和ET水平,并与对照组进行比较。结果 131I治疗前,甲亢心组患者血NO和ET水平与正常对照组比较显著增高(P<0.01),131I治疗3个月后,甲亢心组患者血NO、ET水平较治疗前均显著下降(P<0.01)。结论 131I用于甲亢心的治疗能够显著降低NO和ET水平,改善预后。
Objective To investigate the effects of 131I on the levels of nitric oxide (NO) and endothelin (ET) in patients with hyperthyroid heart disease. Methods Thirty-six cases of 131I treatment of patients with hyperthyroidism were observed before and after treatment of blood NO and ET levels, and compared with the control group. Results Before 131I treatment, the levels of NO and ET in patients with hyperthyroidism heart were significantly higher than those in normal controls (P <0.01). After 3 months of 131I treatment, the levels of NO and ET in patients with hyperthyroidism heart were significantly lower than those before treatment P <0.01). Conclusion 131I for the treatment of hyperthyroid heart can significantly reduce the level of NO and ET, improve prognosis.