论文部分内容阅读
目的 :探讨温补肾阳法 (右归饮、鹿马片 )对激素性股骨头坏死的预防作用 ,并判断动物药 (鹿马片 )和植物药 (右归饮 )的疗效差别。方法 :用外源性糖皮激素诱导家兔股骨头坏死模型为对象 ,从 HPA轴、性激素、组织学角度探讨温补肾阳法对激素性股骨头坏死的预防作用。结果 :右归饮能拮抗激素诱导股骨头坏死HPA轴的抑制状态 ,纠正紊乱的性激素水平。鹿马片亦能拮抗激素诱导股骨头坏死 HPA轴的抑制状态 ,但加剧性激素水平的紊乱。右归饮和鹿马片都能预防激素所致的股骨头坏死 ,且疗效相似。结论 :温补肾阳法能预防激素所致的股骨坏死 ,动植物药二者疗效相似。
Objective: To explore the preventive effect of warming and nourishing kidney-yang (Yongguiyin and Luma tablets) on steroid-induced femoral head necrosis, and to judge the difference in efficacy between animal medicine (Luma tablets) and botanical drugs (Yougui drinking). Methods :The model of femoral head necrosis induced by exogenous glucocorticoids was used as the object. The prevention of steroid-induced femoral head necrosis was studied from the perspective of HPA axis, sex hormones, and histology. Results: Youguiyin could antagonize the inhibitory state of hormone-induced HPA axis in femoral head necrosis and correct the disorder of sex hormone levels. Deer horse tablets can also antagonize hormone-induced osteonecrosis of the femoral head HPA axis inhibition, but exacerbated the level of sex hormone disorders. Youguiyin and Luma tablets can prevent hormone-induced femoral head necrosis and have similar efficacy. Conclusion: Warming kidney-yang can prevent femoral necrosis caused by hormones. Animal and plant medicines have similar efficacy.