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目的：野黄芩甙是半枝莲的主要成分，半枝莲水煎剂对大鼠发热有明显的解热作用。为了证实野黄芩甙是否是半枝莲解热的主要成分，对野黄芩甙的解热作用进行实验研究。方法：Ｗｉｓｔａｒ大鼠背部皮下注射１０％干酵母混悬液制备大鼠发热模型。选取体温上升１℃以上的大鼠７０只，随机分为野黄芩甙１２．５ｍｇ·ｋｇ－１、２５ｍｇ·ｋｇ－１、５０ｍｇ·ｋｇ－１组，阿斯匹林１００ｍｇ·ｋｇ－１、黄芩甙２５ｍｇ·ｋｇ－１、５０ｍｇ·ｋｇ－１和盐水对照组。均腹腔注射给药。药后每小时测量体温１次，连续６次。结果：野黄芩甙ｉｐ给药，对正常大鼠的体温无明显影响，用药前后体温变化差异无显著性（Ｐ＞０．０５）。但对发热大鼠有明显的解热作用，用药前后体温变化差异显著（Ｐ＜０．０１），并有明显的剂量依赖关系。野黄芩甙的解热作用持续４ｈ。野黄芩甙的解热作用强于阿斯匹林。结论：野黄芩甙是半枝莲的主要成分，其解热作用与半枝莲相似，表明野黄芩甙是半枝莲解热作用的主要成分。
Objective: Wild Astragalus is the main component of Scutellaria barbata, and Scutellaria barbata decoction has obvious antipyretic effect on rats. In order to confirm whether wild yellow peony is the main component of Scutellaria barbata’s antipyretic activity, the antipyretic effect of wild buckwheat was studied experimentally. METHODS: A rat febrile model was prepared by subcutaneous injection of 10% dry yeast suspension into the back of Wistar rats. 70 rats whose body temperature increased by 1°C or more were randomly divided into 12.5 mg·kg-1, 25 mg·kg-1, 50 mg·kg-1 groups of ascoticin, 100 mg·kg-1 aspirin, and jaundice.甙25mg·kg-1, 50mg·kg-1 and saline control groups. All intraperitoneal injections. The body temperature was measured once every hour after the drug, 6 times in succession. RESULTS: The ip administration of Scutellaria baicalensis Georgi showed no significant effect on the body temperature of normal rats, and there was no significant difference in body temperature before and after administration (P>0.05). However, there was a significant antipyretic effect on febrile rats. There was a significant difference in body temperature before and after administration (P<0.01), and there was a significant dose-dependent relationship. The antipyretic effect of wild Astragalus continues for 4 h. The antipyretic effect of wild Astragalus is stronger than that of aspirin. Conclusion: Scutellaria baicalensis is the main component of Scutellaria barbata, and its antipyretic effect is similar to that of Scutellaria barbata, indicating that Scutellaria baicalensis is the main component of antipyretic effect of Scutellaria barbata.