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目的观察以伏风理论治疗咳嗽变异型哮喘(CVA)的临床疗效,及其对气道高反应性和抗炎效果的影响。方法将120例患者随机分为2组,每组60例。治疗组以伏风理论拟定的协定基础方加味治疗,对照组以舒氟美口服治疗。比较2组症状积分、第1秒最大用力呼气量(FEV1)、最大呼气流速(PEF)、用力肺活量(FVC)、外周血嗜酸性粒细胞(EOS)计数以及细胞免疫功能IgE等,并比较其临床疗效。结果治疗组症状总积分为(5.00±4.23)分,明显低于对照组(7.19±6.04)分,差异有统计学意义(P<0.05);治疗组肺功能改善情况较对照组明显,差异有统计学意义(P<0.05或P<0.01);治疗组外周血EOS、IgE下降均较对照组明显,差异有统计学意义(P<0.05)。治疗组临床总有效率(80.5%)明显高于对照组(72.2%),差异有统计学意义(P<0.05)。结论以伏风理论治疗CVA疗效显著。
Objective To observe the curative effect of cough variant asthma (CVA) by volt-wind theory and its effect on airway hyperresponsiveness and anti-inflammatory effect. Methods 120 patients were randomly divided into two groups, 60 cases in each group. The treatment group was treated with the basic protocol of the protocol developed by the volt wind theory and the control group was treated orally with shumeflam. The symptom score, FEV1, PEF, FVC, EOS count and IgE of the cellular immune function were compared between the two groups. Compare its clinical efficacy. Results The total score of symptom in the treatment group was (5.00 ± 4.23) points, which was significantly lower than that in the control group (7.19 ± 6.04), the difference was statistically significant (P <0.05). The improvement of pulmonary function in the treatment group was more obvious than that in the control group (P <0.05 or P <0.01). The decrease of EOS and IgE in the peripheral blood of the treatment group was more obvious than that of the control group (P <0.05). The total effective rate of the treatment group (80.5%) was significantly higher than that of the control group (72.2%), the difference was statistically significant (P <0.05). Conclusion The treatment of CVA with volt wind theory has obvious curative effect.