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目的:检测高海拔地区子宫内膜异位症患者血清血管内皮生长因子(VEGF)水平,并探讨其临床意义。方法:收集65例子宫内膜异位症患者和65例对照患者的血清,应用酶联免疫法检测血清血管内皮生长因子(VEGF)的表达。比较高原地区不同临床症状、不同临床分期患者血清血管内皮生长因子(VEGF)的水平差异。结果:高海拔地区子宫内膜异位症患者的血清血管内皮生长因子(VEGF)水平明显高于对照组(P<0.05),痛经症状明显时血清血管内皮生长因子(VEGF)水平则明显升高(P<0.05),尤其(Ⅲ~Ⅳ)期子宫内膜异位症患者的血清血管内皮生长因子(VEGF)水平明显高于(Ⅰ~Ⅱ)期的患者。结论:血清血管内皮生长因子(VEGF)参与了高海拔地区子宫内膜异位症的发生和发展过程,在高海拔地区通过血清血管内皮生长因子(VEGF)的拮抗治疗可能是治疗子宫内膜异位症的有效方法。
Objective: To detect the serum level of vascular endothelial growth factor (VEGF) in patients with endometriosis at high altitude and to explore its clinical significance. Methods: Serum samples of 65 patients with endometriosis and 65 controls were collected. The expression of serum vascular endothelial growth factor (VEGF) was detected by enzyme - linked immunosorbent assay. The differences of serum vascular endothelial growth factor (VEGF) levels in patients with different clinical symptoms and different clinical stages were compared. Results: The serum level of vascular endothelial growth factor (VEGF) in patients with endometriosis at high altitude was significantly higher than that in the control group (P <0.05). The levels of serum vascular endothelial growth factor (VEGF) (P <0.05). In particular, the levels of serum vascular endothelial growth factor (VEGF) in patients with endometriosis (Ⅲ ~ Ⅳ) were significantly higher than those in patients with stage Ⅰ ~ Ⅱ. Conclusion: Serum vascular endothelial growth factor (VEGF) is involved in the development and progression of endometriosis at high altitude. Antagonism of serum vascular endothelial growth factor (VEGF) in high altitude may be the treatment of endometriosis Symptoms of the effective method.