论文部分内容阅读
目的：研究血管升压素的复苏疗效，明确其最适剂量及安全性。方法：８３例心脏停搏患者随机分为４组：标准剂量肾上腺素（ＳＤＥ）组２２例，大剂量肾上腺素（ＨＤＥ）组２１例（此２组肾上腺素首剂用量分别为１．０ｍｇ和５．０ｍｇ，若无效，每５分钟重复首剂量），低剂量血管升压素（ＬＤＶ）组２０例，大剂量血管升压素（ＨＤＶ）组２０例（此２组血管升压素首剂用量分别为０．５Ｕ／ｋｇ和１．０Ｕ／ｋｇ，若无效，每１０分钟重复首剂量）。结果：ＨＤＶ组、ＬＤＶ组、ＨＤＥ组和ＳＤＥ组的自主循环恢复率分别为７０．０％、５０．０％、４８．５％和１８．２％，ＨＤＶ组显著高于其他３组（Ｐ＜０．０５或Ｐ＜０．０１）；ＨＤＶ组的存活率为３５．０％显著高于ＬＤＶ组存活率１５．０％、ＨＤＥ组存活率１４．３％和ＳＤＥ组存活率４．５％（Ｐ均＜０．０５）；ＨＤＶ组、ＬＤＶ组、ＨＤＥ组和ＳＤＥ组的自主循环恢复平均时间分别为（６．１±２．０）分、（９．３±１．４）分、（１２．３±１．８）分和（１５．７±５．１）分，ＨＤＶ组较其他３组明显缩短（Ｐ＜０．０５，Ｐ＜０．０１，Ｐ＜０．００１）。ＬＤＶ组与ＨＤＥ组自主循环恢复率相近，但前者的自主循环恢复平均时间明显短于后者?
Objective: To study the effect of vasopressin recovery and determine the optimal dose and safety. Methods: Totally 83 patients with cardiac arrest were randomly divided into 4 groups: 22 in standard dose epinephrine (SDE) group and 21 in HDE group (the first dose of epinephrine was 1.0 mg and 5.0mg, if invalid, repeat the first dose every 5 minutes), 20 cases of low dose of vasopressin (LDV) and 20 cases of high dose of vasopressin (HDV) The dosage was 0.5U / kg and 1.0U / kg, respectively, if invalid, repeat the first dose every 10 minutes). Results: The recovery rates of spontaneous circulation in HDV, LDV, HDE and SDE groups were 70.0%, 50.0%, 48.5% and 18.2%, respectively, which were significantly higher in HDV group than those in other three groups <0.05 or P <0.01). The survival rate of HDV group was 35.0%, which was significantly higher than that of LDV group (15.0%), HDE group (14.3%) and SDE group % Respectively (all P <0.05). The average recovery time of spontaneous circulation in HDV, LDV, HDE and SDE groups were (6.1 ± 2.0) and (9.3 ± 1.4) , (12.3 ± 1.8) points and (15.7 ± 5.1) points respectively. HDV group was significantly shorter than the other three groups (P <0.05, P <0.01, P <0.001) . LDV group and HDE group spontaneous circulation recovery rate similar, but the former spontaneous circulation recovery time was significantly shorter than the latter?