对无法手术切除的结肠直肠癌转移灶行氟尿嘧啶生物调节治疗:2例存活超过10年的病例报道

• 作 者: Leonard G.D. Kemeny N.E. 廖新华
• 机 构: Memorial Sloan-Kettering Cancer Center 1275 York Avenue,New York,NY 10021,United States Dr.,
• 出 处: 世界核心医学期刊文摘(胃肠病学分册)
• 发表日期: 2006年09期
• 关键词: 结肠直肠癌 尿嘧啶 生物调节 肝转移灶 手术 叶酸 病例 外科切除 甲氨蝶呤 姑息性治疗

The treatment of metastatic colorectal cancer by chemotherapy alone was considered palliative and without the potential to cure patients unless patients were rendered resectable.We report two patients with metastatic colorectal cancer involving the liver who were considered inoperable andwere treated with systemic chemotherapy using biomodulated 5-fluorouracil.Both patients received 5-fluorouracil and N-(phosphonoacetyl)-l-aspartic acid;one also received methotrexate,leucovorin,and triacetyluridine with the N-(phosphonoacetyl)-l-aspartic acid and 5-fluorouracil.Both patients had a complete remission with chemotherapy and are still alive with no evidence of cancer ten years after the diagnosis of unresectable metastatic disease.These patients provide evidence that prolonged survival can be achieved with systemic chemotherapy without the use of surgery or other forms of local therapy.These patients also confirm the importance of continued investigation of fluorouracil modulating agents,which may further enhance the recent progress made with fluorouracil-based combination chemo-therapy for colorectal cancer.

The treatment of metastatic colorectal cancer by chemotherapy alone was considered palliative and without the potential to cure patients unless patients were rendered resectable. We report two patients with metastatic colorectal cancer involving the liver who were considered inoperable and we treated with integrated chemotherapy using biomodulated 5-fluorouracil .Both patients received 5-fluorouracil and N- (phosphonoacetyl) -l-aspartic acid; one also received methotrexate, leucovorin, and triacetyluridine with the N- (phosphonoacetyl) -l-aspartic acid and 5-fluorouracil.Both patients had a complete remission with chemotherapy and are still alive with no evidence of cancer ten years after the diagnosis of unresectable metastatic disease. These patients provide evidence that prolonged survival can be achieved with systemic chemotherapy without the use of surgery or other forms of local therapy. these patients also confirm the importance of continued investigation of fluorouracil modulating agents, w hich may further enhance the recent progress made with fluorouracil-based combination chemo-therapy for colorectal cancer.