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目的研究茵兰益肝颗粒治疗急性药物性肝损伤的作用机制及治疗效果。方法选择辛集市中医院2011年1月至2012年1月收治的56例药物性肝损伤患者,随机分为两组,观察组28例患者给予茵兰益肝颗粒治疗,对照组28例患者给予西利宾胺片,比较两组患者临床症状及肝功能指标等改善情况。结果两组综合疗效比较结果:观察组总有效率为92.86%,对照组总有效率为82.14%,观察组治疗效果明显高于对照组,两组比较差异具有统计学意义(P<0.05)。比较两组患者治疗后中医证候疗效,观察组总有效率为92.86%;对照组总有效率为92.86%;两组比较差异无统计学意义(P>0.05)。比较两组患者治疗后超声疗效显示,观察组总有效率为89.29%,对照组总有效率为92.86%,两组比较差异无统计学意义(P>0.05)。结论茵兰益肝颗粒治疗急性药物性肝损伤临床症状改善情况好于西药治疗,作用机制是对肝细胞的炎症反应产生抑制作用。
Objective To study the mechanism and therapeutic effect of Yinranyigan Granules on acute drug-induced liver injury. Methods Sixty-six patients with drug-induced liver injury who were admitted to Xinji Hospital of Traditional Chinese Medicine from January 2011 to January 2012 were randomly divided into two groups. 28 patients in the observation group were treated with Yinranyigan Granules and 28 in the control group Silibin tablets, clinical symptoms and liver function indicators were compared between two groups to improve the situation. Results The results of the two groups were compared. The total effective rate was 92.86% in the observation group and 82.14% in the control group. The treatment effect in the observation group was significantly higher than that in the control group. There was significant difference between the two groups (P <0.05). The total effective rate of the observation group was 92.86%. The total effective rate of the control group was 92.86%. There was no significant difference between the two groups (P> 0.05). Comparison of the two groups of patients after treatment of ultrasound showed that the total effective rate was 89.29% in the observation group, the control group was 92.86%, the difference between the two groups was not statistically significant (P> 0.05). Conclusion The improvement of the clinical symptoms of Yili Gangye Granules on acute drug-induced liver injury is better than that of western medicine. The mechanism of action is to inhibit the inflammatory reaction of hepatocytes.