论文部分内容阅读
用放射免疫分析技术测定大鼠在６００ｋＰａ高压氧暴露下海马、纹状体和额叶皮质中生长抑素（ＳＳ）含量的变化，并在７００ｋＰａ高压氧暴露下，观察腹腔内注射半胱胺（ＣＳＨ）及侧脑室内注射ＳＳ抗血清对大鼠氧惊厥始发时间（Ｉｎｉｔｉａｌｔｉｍｅｏｆｃｏｎｖｕｌｓｉｏｎ；ＩＴＣ）、惊厥严重程度（Ｓｅｖｅｒｉｔｙｏｆｃｏｎｖｕｌｓｉｏｎ；ＳＯＣ）和氧惊厥大鼠存活时间（Ｓｕｒｖｉｖａｌｔｉｍｅ；ＳＴ）的影响。结果显示大鼠濒临氧惊厥时海马、纹状体中ＳＳ含量显著升高，氧惊厥时所观察脑区ＳＳ含量均显著升高；ＣＳＨ和ＳＳ抗血清预处理显著延迟大鼠ＩＴＣ，减轻ＳＯＣ和延长其ＳＴ。提示ＳＳ可能参与氧惊厥发作过程，并可能是导致氧惊厥的内源性物质之一。
The changes of somatostatin (SS) content in hippocampus, striatum and frontal cortex of rats exposed to hyperbaric oxygen at 600kPa were measured by radioimmunoassay. Under high pressure oxygen exposure of 700kPa, intraperitoneal injection of cysteamine (CSH) and intracerebroventricular (SS) injection of antiserum against SS on the ITC, SOC, and the survival time of oxygen-induced convulsive rats. The results showed that the content of SS in hippocampus and striatum of rats on the verge of oxygen convulsion was significantly increased, and the contents of SS in brain were significantly increased at the time of oxygen convulsion. Pretreatment with CSH and SS antiserum significantly delayed the ITC, Extend its ST. Suggesting that SS may be involved in the process of oxygen seizures and may be one of the endogenous substances that cause oxygen convulsion.