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目的:探讨原发骨肉瘤与骨转移瘤肿瘤中的血管内皮生长因子(VEGF)表达水平。方法:选取34例骨肉瘤以及16例骨转移瘤患者肿瘤组织纳入研究,另选取10例同时期单纯骨折患者组织标本作为对照。运用免疫组化法检测3种组织VEGF表达,并比较不同骨组织VEGF表达水平差异。结果:骨肉瘤患者、骨转移瘤患者VEGF表达均高于正常对照组,差异具有显著性意义(P<0.01),骨转移瘤与骨肉瘤肿瘤组织VEGF表达水平差异无统计学意义(P>0.05)。不同组织学分型骨肉瘤VEGF阳性表达比较差异无统计学意义(P>0.05)。结论:VEGF在骨肉瘤与骨转移瘤组织中表达异常增高。在不同类型骨肿瘤组织之间及不同组织学分型骨肉瘤之间VEGF表达无显著差异性。
Objective: To investigate the expression of vascular endothelial growth factor (VEGF) in primary osteosarcoma and bone metastases. Methods: Tumor tissues from 34 patients with osteosarcoma and 16 patients with bone metastases were enrolled in this study. Tissue samples from 10 patients with simple fracture at the same time were selected as control. The expression of VEGF in the three tissues was detected by immunohistochemistry, and the differences of VEGF expression in different tissues were compared. Results: The expression of VEGF in osteosarcoma patients and bone metastases patients was significantly higher than that in normal control group (P <0.01). There was no significant difference in VEGF expression between osteosarcoma and osteosarcoma (P> 0.05 ). There was no significant difference in VEGF positive expression between different histological types of osteosarcoma (P> 0.05). Conclusion: The expression of VEGF in osteosarcoma and bone metastases increased abnormally. There was no significant difference in VEGF expression between different types of bone tumor and between different histological types of osteosarcoma.