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[目的]探讨疏肝健脾补肾方联合阿德福韦酯(ADV)治疗慢性乙型肝炎(CHB)的临床疗效。[方法]将51例CHB患者随机分成A(疏肝健脾补肾方)、B(疏肝健脾补肾方加ADV)、C(ADV)3组。每组17例。治疗6个月后对3组患者临床症状、体征、疗效、肝功能、血清乙肝病毒(HBV)DNA水平及血清标志物等指标进行观察比较。[结果]B组在胁肋胀痛、腹胀便溏、畏寒肢冷、少腹腰膝冷痛等症状改善及丙氨酸氨基转移酶复常率方面均优于其他2组。3组治疗前后HBV DNA转阴率、HBV DNA水平比较差异有统计学意义,以B组为甚。[结论]中西医结合治疗CHB比单一使用中药或西药在临床症状改善、肝功能恢复、抑制HBV复制等方面的效果更好。
[Objective] To explore the clinical effect of Shugan Jianpi Bushen Recipe combined with adefovir dipivoxil (ADV) on chronic hepatitis B (CHB). [Method] 51 CHB patients were randomly divided into A (Shugan Jianpishenzheng Decoction), B (Shugan Jianpishenzhengfang ADV) and C (ADV) 3 groups. 17 cases in each group. After 6 months of treatment, the clinical symptoms, signs, curative effect, liver function, serum HBV DNA levels and serum markers were observed and compared among the three groups. [Result] The B group was better than the other two groups in improving the symptoms such as flank pain, bloating stool, aversion to cold and limbs, cold pain in lower abdomen and lumbar and knee and alanine aminotransferase. Before and after treatment, HBV DNA negative rate and HBV DNA level had statistical significance, especially in group B. [Conclusion] Integrative Chinese and Western medicine treatment of CHB than single use of traditional Chinese medicine or Western medicine in improving clinical symptoms, liver function recovery, inhibition of HBV replication and so on better.